Development of a new screening tool for cyber pornography. Psychometric properties of the Cyber Pornography Addiction Test (CYPAT)

Objective: Internet pornography addiction typically involves viewing, downloading and trading online pornography or engagement in adult fantasy role-play. There are some well-validated inventories measuring perceived addiction to internet pornography but these instruments are often too long for a functionally use and fast scoring. The aim of this study was to evaluate the psychometric properties of the cyber pornography addiction test (CYPAT), a new, brief, screening measure for assessing cyber pornography.Method: Participants of this study completed the CYPAT, the CPUI, the TAS-20 and the FACES-IV. Descriptive statistics were calculated and Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were applied.Results: Cronbach's alpha coefficient suggested excellent reliability of the measure. Results of this study revealed also good construct, convergent and divergent validity.Conclusions: CYPAT is a brief self-report screening scale composed of 11 items scored on a five-point Likert scale with good psychometrics properties. The implications of these findings for future theoretical and empirical research in this field are discusse

Material-informed topology optimization for Wire-and-Arc Additive Manufacturing

Wire-and-Arc Additive Manufacturing (WAAM) is a metal 3d printing technique that allows fabricating elements ranging from simple geometry to extremely complex shapes. “Layer-by-layer” manufacturing produces a printed material with significant elastic anisotropy, whereas “dot-by-dot” printing may be used to fabricate funicular geometries in which the mechanical properties of the single bars are affected by the printing process. The design of WAAM components is addressed by formulating problems of structural optimizations that account for the peculiar features of the printed alloy. Topology optimization by distribution of anisotropic material is exploited to find optimal shapes in layer-by-layer manufacturing. Two-dimensional specimens are addressed along with I-beams. In the latter case it is assumed that a web plate and two flanges are printed and subsequently welded to assemble the structural component. A constrained force density method is proposed for the design of grid shells in dot-by-dot printing, formulating local enforcements to govern the magnitude of the axial force in each branch of the network. In both formulations, the arising multi-constrained problem is efficiently tackled through methods of sequential convex programming. Lightweight solutions for layer-by-layer and dot-by-dot manufacturing are found for given printing directions. Extensions of the proposed numerical tools are highlighted to endow the optimization problems with additional set of materialrelated constraints

A numerical approach to the design of gridshells for WAAM

A novel approach based on funicular analysis is investigated to cope with the design of spatial truss networks fabricated by Wire-and-Arc Additive Manufacturing (WAAM). The minimization of the horizontal thrusts of networks with fixed plan geometry is stated both in terms of any independent subset of the force densities and in terms of the height of the restrained nodes. Local enforcements are formulated to prescribe lower and upper bounds for the vertical coordinates of the nodes, and to control the stress regime in the branches. This allows also for a straightforward control of the length and maximum force magnitude in each branch. Constraints are such that sequential convex programming can be conveniently exploited to handle grids with general topology and boundary conditions. Optimal networks for WAAM are preliminary investigated, accounting for different sets of the above prescriptions

Seismic-proof buildings in developing countries

The use of \u201cductile seismic frames,\u201d whose proper seismic behavior largely depends upon construction details and specific design rules, may do not always lead to effective seismic resistant structures, as dramatically denounced by the famous Chinese artist Ai Weiwei in his artwork Straight. The artwork (96 t of undulating metal bars that were salvaged from schools destroyed by the 2008 Sichuan, China earthquake, where over 5,000 students were killed) is a clear denounce against the corruption yielding to shoddy construction methods. The issue of safe constructions against natural hazards appears even more important in developing countries where, in most cases, building structures are realized by non-expert workers, or even by simple \u201cpeople from the street,\u201d who does not have any technical knowledge on construction techniques and seismic engineering. In this paper, a brief history from the first frame structures to the more efficient wall-based structures is provided within Earthquake Engineering perspectives. The superior structural properties of box-type wall structures with respect to conventional frame structures envisage a change of paradigm from actual \u201cductility-based\u201d Earthquake Engineering (centered on frame structures) toward 100% safe buildings through a \u201cstrength-based\u201d design exploiting the use of box-type wall-based structures

Blended structural optimization for wire-and-arc additively manufactured beams

Current manufacturing techniques in the construction sector are slow, expensive and constrained in terms of architectural shapes. In other manufacturing sectors (such as automotive and aerospace) the use of automated construction systems significantly improved the safety, speed, quality and complexity of products. To realize real-scale structural elements for construction applications without ideally any geometrical constraints either in size or shape, the most suitable manufacturing solution for metallic elements is a directed energy deposition (DED) process referred to as wire-and-arc additive manufacturing (WAAM). The main advantage of WAAM relies on the possibility to create new shapes and forms following the breakthrough design tools for modern architecture as algorithm-aided design. At the same time, the printed part ensures high structural performances with reduced material use with respect to the conventional solution. The study presents a new approach called “blended” structural optimization, which blends topology optimization with basic principles of structural design and manufacturing constraints proper of WAAM technology, towards the realization of new efficient structural elements. The approach is applied to the case study of a I-type stainless steel beam on a multi-storey frame building. The approach could pave the way towards an efficient use of WAAM process to produce a new generation of structurally optimized elements for construction, with a more conscious use of the optimization tools and an efficient application of metal 3D printing

Magnetic resonance tumor regression grade (MR-TRG) to assess pathological complete response following neoadjuvant radiochemotherapy in locally advanced rectal cancer

This study aims to evaluate the feasibility of a magnetic resonance (MR) automatic method for quantitative assessment of the percentage of fibrosis developed within locally advanced rectal cancers (LARC) after neoadjuvant radiochemotherapy (RCT). A total of 65 patients were enrolled in the study and MR studies were performed on 3.0 Tesla scanner; patients were followed-up for 30 months. The percentage of fibrosis was quantified on T2-weighted images, using automatic K-Means clustering algorithm. According to the percentage of fibrosis, an optimal cut-off point for separating patients into favorable and unfavorable pathologic response groups was identified by ROC analysis and tumor regression grade (MR-TRG) classes were determined and compared to histopathologic TRG. An optimal cut-off point of 81% of fibrosis was identified to differentiate between favorable and unfavorable pathologic response groups resulting in a sensitivity of 78.26% and a specificity of 97.62% for the identification of complete responders (CRs). Interobserver agreement was good (0.85). The agreement between P-TRG and MR-TRG was excellent (0.923). Significant differences in terms of overall survival (OS) and disease free survival (DFS) were found between favorable and unfavorable pathologic response groups. The automatic quantification of fibrosis determined by MR is feasible and reproducible

Radiogenomics in clear cell renal cell carcinoma: correlations between advanced CT imaging (texture analysis) and microRNAs expression

Purpose: A relevant challenge for the improvement of clear cell renal cell carcinoma management could derive from the identification of novel molecular biomarkers that could greatly improve the diagnosis, prognosis, and treatment choice of these neoplasms. In this study, we investigate whether quantitative parameters obtained from computed tomography texture analysis may correlate with the expression of selected oncogenic microRNAs. Methods: In a retrospective single-center study, multiphasic computed tomography examination (with arterial, portal, and urographic phases) was performed on 20 patients with clear cell renal cell carcinoma and computed tomography texture analysis parameters such as entropy, kurtosis, skewness, mean, and standard deviation of pixel distribution were measured using multiple filter settings. These quantitative data were correlated with the expression of selected microRNAs (miR-21-5p, miR-210-3p, miR-185-5p, miR-221-3p, miR-145-5p). Both the evaluations (microRNAs and computed tomography texture analysis) were performed on matched tumor and normal corticomedullar tissues of the same patients cohort. Results: In this pilot study, we evidenced that computed tomography texture analysis has robust parameters (eg, entropy, mean, standard deviation) to distinguish normal from pathological tissues. Moreover, a higher coefficient of determination between entropy and miR-21-5p expression was evidenced in tumor versus normal tissue. Interestingly, entropy and miR-21-5p show promising correlation in clear cell renal cell carcinoma opening to a radiogenomic strategy to improve clear cell renal cell carcinoma management. Conclusion: In this pilot study, a promising correlation between microRNAs and computed tomography texture analysis has been found in clear cell renal cell carcinoma. A clear cell renal cell carcinoma can benefit from noninvasive evaluation of texture parameters in adjunction to biopsy results. In particular, a promising correlation between entropy and miR-21-5p was found

Combined Additive Manufacturing Techniques for Adaptive Coastline Protection Structures

Traditional reinforcement cages are manufactured in a handicraft manner and do not use the full potential of the material, nor can they map from optimised geometries. The shown research is focused on robotically-manufactured, structurally-optimised reinforcement structures which are prefabricated and can be encased by concrete through SC3DP in a combined process. Based on the reinforcement concept of “reinforcement supports concrete,” the prefabricated cages support the concrete during application in a combined AM process. To demonstrate the huge potential of combined AM processes based on the SC3DP and WAAM techniques (for example, the manufacturing of individualized CPS), the so-called FLOWall is presented here. First, the form-finding process for the FLOWall concept based on fluid dynamic simulation is explained. For this, a three-step strategy is presented, which consists of (i) the 3D modelling of the element, (ii) the force-flow analysis, and (iii) the structural validation in a computational fluid dynamics software. From the finalized design, the printing phase is divided into two steps, one for the WAAM reinforcement and one for the SC3DP wall. The final result provides a good example of efficient integration of two different printing techniques to create a new generation of freeform coastline protection structures

The use of sodium bicarbonate for marination of broiler breast meat

This study aimed at evaluating marination performances and effect on meat quality traits of sodium bicarbonate, used alone or in combination with sodium chloride, when compared with sodium trypolyphosphate by using advanced analytical tools including low-field nuclear magnetic resonance (LF-NMR) and differential scanning calorimetry (DSC). A total of 140 samples (cylindrical shape of 1×4 cm size) were obtained from a batch of 24h post mortem broiler breast meat (Ross 708, females, 47 day-old). Six of the groups were used for subsequent marination treatments, while the last group was kept as non-marinated control (C). Samples were subjected to vacuum tumbling in a special equipped laboratory rotary evaporator with a 12% (w/w) water:meat ratio using 6 marinade solutions: 7.7% (w/w) NaCl (S); 2.3% Na4O7P2 (w/w) (P); 2.3% (w/w) NaHCO3 (B); 7.7% (w/w) NaCl and 2.3% Na4O7P2 (w/w) (SP); 7.7% (w/w) NaCl and 2.3% (w/w) NaHCO3 (SB); 7.7% (w/w) NaCl, 2.3% Na4O7P2 (w/w) and 2.3% (w/w) NaHCO3 (SPB). Samples marinated with bicarbonate alone or in combination (B, SB and SPB) significantly increased (P<0.05) meat pH by approximately 0.7 units compared to the control, whilst phosphate alone or in combination with salt increased (P<0.05) the pH by 0.2 units. Combination containing all ingredients (SPB) produced the highest marinade performances, however sodium bicarbonate with salt (SB) was able to guarantee a better marinade uptake and water retention ability in respect to phosphates (SP). According to LR-NMR, the combined use of bicarbonate and/or phosphate with sodium chloride determined a remarkable increase of proportion of entrapped water into myofibrillar spaces, while extra-myofibrillar water fraction was not modified. Moreover water gain following marination does not correspond to an increase of freezable water amount as detected by DSC. In conclusion, bicarbonate is a very promising marinating agent and it can be exploited to develop processed poultry products with no added phosphates in order to match the request to avoid the nutritional drawbacks recently indicated with the use of phosphates